Development of soil ecotoxicogenomic endpoints and benchmark dose modeling for streamlined chemical risk assessment

Funding period: 2020-2024
Lead: Julia Princz
Total GRDI funding: $71,000

Toxicogenomic profiles are lacking for sentinel soil species used within current ecological risk assessment regimes, despite the global harmonization of toxicological methods and species. We aim to evaluate and demonstrate the applicability of genomic-scale analysis for the derivation of benchmark doses for the protection of species against soil contaminants. This will be accomplished through genomic profiles associated with soil invertebrate species exposed to different soil contaminants. Deliverables include a series of tools and methods that can serve as guidance for the integration and application of genomic-scale analyses to the risk assessment of contaminants in soil.