Funding period: 2019-2024
Lead: Sabina Halappanavar
Total GRDI funding: $870,000
Engineered nanomaterials are a novel class of materials that are 1-100 nanometres in size. Health Canada is responsible for regulating products that contain such materials. When inhaled, engineered nanomaterials can induce harmful effects in experimental animals; however, quality toxicological data are currently not available for an effective assessment of risk to human health. This project generates experimental data to support the risk assessment of a select set of nanaomaterials. The acquired knowledgebase and methods can be used by Health Canada to screen for potential toxicities of novel nanomaterials of concern in Canada.
Publications
- Boyadzhiev A, Avramescu M-L, Wu D, Williams A, Rasmussen P. 2021. Impact of copper oxide particle solubility on lung epithelial cell toxicity: response characterization using global transcriptional analysis. Nanotoxicology. Nanotoxicology. 15(3):380-399. https://doi.org/10.1080/17435390.2021.1872114
- Doak SH, Clift MJD, Costa A, Delmaar C, Gosens I, Halappanavar S, Kelly S, Pejinenburg WJGM, Rothen-Rutishauser B, Schins RPF, Stone V, Tran L, Vijver MG, Vogel U, Wohlleben W, Cassee FR. 2022. The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies. Small. 2022 Apr;18(17):e2200231. https://doi.org/10.1002/smll.202200231
- Halappanavar S, Ede JD, Krug HF, Mahapatra I, Krug HF, Kuempel ED, Lynch I, Vandebriel RJ, Shatkin JA. 2021. A methodology for developing key events to advance nanomaterial-relevant adverse outcome pathways to inform risk assessment. Nanotoxicology. 15(3):289-310. https://doi.org/10.1080/17435390.2020.1851419
- Halappanavar S, Ede JD, Shatkin JA, Krug HF. 2019. A systematic process for identifying key events for advancing the development of nanomaterial relevant adverse outcome pathways. NanoImpact. 15:e100178. https://doi.org/10.1016/j.impact.2019.100178
- Halappanavar S, Nymark P, Krug HF, Martin JD, Clift MJD, Rothen-Rutishauser B, Vogel U. 2021. Non-animal strategies for toxicity assessment of nanoscale materials: role of adverse outcome pathways in the selection of endpoints. Small. 17(15):e 2007628 https://doi.org/10.1002/smll.202007628
- Halappanavar S, Rahman L, Nikota J, Poulsen SS, Ding Y, Jackson P, Wallin H, Schmid O, Vogel U, Williams A. 2019. Ranking of nanomaterial potency to induce pathway perturbations associated with lung responses. NanoImpact. 14:e100158. https://doi.org/10.1016/j.impact.2019.100158
- Halappanavar S, van den Brule S, Nymark P, Gaté L, Seidel C, Valentino S, Zhernovkov V, Høgh Danielsen P, De Vizcaya A, Wolff H, Stöger T, Boyadziev A, Poulsen SS, Sørli JB, Birkelund J, Vogel U. 2020. Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale. Part. Fibre Toxicol. 17(1):16. https://doi.org/10.1186/s12989-020-00344-4
- Nymark P, Karlsson HL, Halappanavar S, Vogel U. 2021. Adverse Outcome Pathway Development for Assessment of Lung Carcinogenicity by Nanoparticles. Front Toxicol. 3:653386. https://doi.org/10.3389/ftox.2021.653386
- Poulsen SS, Bengston S, Williams A, Jacobsen NR, Troelsen JT, Halappanavar S, Vogel U. 2021. A transcriptomic overview of lung and liver changes one day after pulmonary exposure to graphene and graphene oxide. Toxicol. Appl. Pharmacol. 410:e115343. https://doi.org/10.1016/j.taap.2020.115343
- Jagiello K, Halappanavar S, Rybińska-Fryca A, Willliams A, Vogel U, Puzyn T. 2021. Transcriptomics-based and AOP-informed structure-activity relationships to predict pulmonary pathology induced by multiwalled carbon nanotubes. Small. 17(15):e2003465. https://doi.org/10.1002/smll.202003465
- Rahman L, Williams A, Gelda K, Nikota J, Wu D, Vogel U, Halappanavar S. 2020. 21st century tools for nanotoxicology: transcriptomic biomarker panel and precision-cut lung slice srgan mimic system for the assessment of nanomaterial-induced lung fibrosis. 16(36):e2000272. https://doi.org/10.1002/smll.202000272
- Saber AT, Hadrup N, Williams A, Mortensen A, Szarek J, Kyjovska Z, Kurz A, Jacobsen NR, Wallin H, Halappanavar S, Vogel U. 2022. Unchanged pulmonary toxicity of ZnO nanoparticles formulated in a liquid matrix for glass coating. Nanotoxicology. 2022 Aug-Oct;16(6-8):812-827. https://doi.org/10.1080/17435390.2022.2152751
- Serra A, Del Giudice G, Kinaret PAS, Saarimäki LA, Poulsen SS, Fortino V, Halappanavar S, Vogel U, Greco D. 2022. Characterization of ENM Dynamic Dose-Dependent MOA in Lung with Respect to Immune Cells Infiltration. Nanomaterials (Basel). 2022 Jun 13;12(12):2031. https://doi.org/10.3390/nano12122031
- Solorio-Rodriguez SA, Williams A, Poulsen SS, Knudsen KB, Jensen KA, Clausen PA, Danielsen PH, Wallin H, Vogel U, Halappanavar S. 2023. Single-Walled vs. Multi-Walled Carbon Nanotubes: Influence of Physico-Chemical Properties on Toxicogenomics Responses in Mouse Lungs. Nanomaterials (Basel). 2023 Mar 15;13(6):1059. https://doi.org/10.3390/nano13061059
Contact us
For additional information, please contact:
Genomics R&D Initiative
Email: info@grdi-irdg.collaboration.gc.ca